Show Summary Details
Introduction to Bioinformatics

Introduction to Bioinformatics

Arthur M. Lesk
Page of

Printed from Oxford Science Trove. Under the terms of the licence agreement, an individual user may print out a single article for personal use (for details see Privacy Policy and Legal Notice).

date: 24 June 2024

9. Metabolic pathwayslocked

9. Metabolic pathwayslocked

  • Arthur M. LeskArthur M. LeskThe Pennsylvania State University

Abstract

This chapter explores metabolic pathways, which are the road maps defining the possible transformations of metabolites. They form a network, representable as a graph, usually with the metabolites as nodes, and reactions connecting them as edges. The enzyme that catalyses each reaction labels the edge. The chapter then looks at the defining principles of the Enzyme Commission and the Gene Ontology ConsortiumTM classifications of the functions of biological molecules. It considers the importance of accurate annotation of enzyme function in databases, before outlining the databases of metabolic networks. The chapter also discusses the physicochemical basis of enzymatic catalysis, and the quantities needed to characterize their kinetics. Finally, it examines how the algorithms for comparison of nucleic acid and amino acid sequences can be generalized to compare and align metabolic pathways.

You do not currently have access to this article

Login

Please login to access the full content.

Subscribe

Access to the full content requires a subscription