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Molecular Biology of RNA

Molecular Biology of RNA (Second Edition)

David Elliott and Michael Ladomery
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date: 18 July 2024

p. 295 14 The biogenesis and nucleocytoplasmic traffic of non-coding RNAslocked

p. 295 14 The biogenesis and nucleocytoplasmic traffic of non-coding RNAslocked

  • David ElliottDavid ElliottInstitute of Genetic Medicine, Newcastle University
  •  and Michael LadomeryMichael LadomeryFaculty of Health and Applied Science, University of the West of England

Abstract

This chapter explores non-coding RNAs (ncRNAs) that are processed during their biogenesis. It covers the processing and maturation of ribosomal RNA (rRNA), small nuclear RNA (snRNA), transfer RNA (tRNA), mitochondrial transcripts, and telomerase. It also gives an overview of the important aspects of RNA processing, including the RNA processing machinery that involves the action of other RNA molecules. The chapter reviews the main features of the biogenesis of ribosomal RNA, which is a process that is facilitated by a family of small RNA molecules known as the small nucleolar RNAs (snoRNAs). It describes the organization of rRNA processing in an important multifunctional nuclear organelle, the nucleolus.

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