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Molecular Biology of RNA

Molecular Biology of RNA (Second Edition)

David Elliott and Michael Ladomery
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date: 18 July 2024

p. 334 15 The ‘macro’ RNAs: long non-coding RNAs and epigeneticslocked

p. 334 15 The ‘macro’ RNAs: long non-coding RNAs and epigeneticslocked

  • David ElliottDavid ElliottInstitute of Genetic Medicine, Newcastle University
  •  and Michael LadomeryMichael LadomeryFaculty of Health and Applied Science, University of the West of England


This chapter deals with long non-coding RNAs (ncRNAs) which are transcribed from separate genes and are between 5,000 and 15,000 individuals. It explains that long ncRNAs are transcribed by RNA polymerase II and are spliced to give the final ncRNA, but do not have any open reading frames to encode proteins. It also focuses on the long class of ncRNAs. These are referred to as macroRNAs, which are involved in the epigenetic regulation of gene expression. The chapter mentions important groups of shorter ncRNAs that have partially overlapping functional roles in directing epigenetics, including the siRNAs and rasiRNA. It discusses the specific roles of RNA molecules in controlling gene expression through epigenetic mechanisms.

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