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Molecular Biology of RNA

Molecular Biology of RNA (Second Edition)

David Elliott and Michael Ladomery
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date: 18 July 2024

p. 604. The RNA-binding proteinslocked

p. 604. The RNA-binding proteinslocked

  • David ElliottDavid ElliottInstitute of Genetic Medicine, Newcastle University
  •  and Michael LadomeryMichael LadomeryFaculty of Health and Applied Science, University of the West of England


This chapter details how RNA-binding proteins package RNA, protect RNA, organize RNA, and prepare RNA for post-transcriptional processes. It describes different kinds of RNA-binding and auxiliary domains that enable RNA-binding proteins to bind RNA in a versatile way. It also mentions hnRNP proteins, which are the first RNA-binding proteins to be studied in some detail. The chapter discusses the hnRNP proteins that package premRNA. These are involved in multiple post-transcriptional processes. Also, hnRNP proteins remain bound to messenger RNA in the cytoplasm in mRNP particles. The chapter covers the RNA recognition motif, which is a sequence of amino acids or a specific arrangement of secondary structure.

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