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Molecular Biology of RNA

Molecular Biology of RNA (Second Edition)

David Elliott and Michael Ladomery
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date: 18 July 2024

p. 845. Pre-mRNA splicing by the spliceosomelocked

p. 845. Pre-mRNA splicing by the spliceosomelocked

  • David ElliottDavid ElliottInstitute of Genetic Medicine, Newcastle University
  •  and Michael LadomeryMichael LadomeryFaculty of Health and Applied Science, University of the West of England

Abstract

This chapter focuses on an important development in eukaryotic RNA processing, which is pre-mRNA splicing catalysed by the spliceosome. It explains that spliceosomal splicing is needed as a large proportion of eukaryotic genes are split between segments called introns and exons. The chapter also points out that splicing occurs in the nucleus during transcription and both the introns and exons of split genes are transcribed within the nucleus into long pre-mRNAs. The chapter mentions the origin of the name exon, which derives from the fact that exon sequences are EXpressed, while introns are removed by splicing and so are not expressed in the mature mRNA. It considers the biology of splicing.

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