Drug Design and Development outlines the processes involved in the design and development of new drugs and emphasizes the significance of these processes to the practice of pharmacy. It is composed of five parts. Part 1 considers drug targets and includes receptors and signal transduction, enzymes, nucleic acids, and protein synthesis. Part 2 examines the origins of drug molecules. It discusses sources of lead compounds, drug synthesis, computer-aided drug design, combinatorial chemistry, high-throughput screening, and biotechnology and biopharmaceuticals. Part 3 considers the biological aspects of drug development including drug metabolism, pharmacogenetics, pharmacogenomics, and toxicity testing. Part 4 looks at preformulation studies. The last part covers clinical research.
Book
Graham L. Patrick
An Introduction to Drug Synthesis explores the central role that organic synthesis plays in the process of drug design and development. Part A of the book introduces major concepts and begins by outliningfirstly looks at the drug discovery process. Other chapters in the first part of the text then examines topics such as drug synthesis, retrosynthesis, cycliccycle systems in drug synthesis, and the synthesis of chiral drugs. There is also a chapter on combinational and parallel synthesis. Part B of the book moves on to consider the applications of drug synthesis in the drug development process and. This includes chapters on the synthesis of lead compounds, analogue synthesis in drug design, synthesis of natural products, chemical and process development, and synthesis of isotopically labelled compounds. The final partPart C, the final part of the text, looks at the design and synthesis of selected antibacterial agents.
Book
Graham L. Patrick
An Introduction to Medicinal Chemistry delves into all aspects of this multidisciplinary field. Firstly, the text introduces and presents an overview. Chapters then look at drug targets, their structure, and their function. They examine proteins, enzymes, receptors, and nucleic acids. The next group of chapters is about pharmacodynamics and pharmacokinetics. Then the text turns to look at drug discovery, design, and development. It presents case studies. After this, the chapters look at tools and included is an examination of computers used in medicinal chemistry. Finally, the text presents a number of topics in medicinal chemistry such as antibacterial agents, antiviral agents, anticancer agents, opioid analgesics, and antiulcer agents.
Book
Chris Rostron and Jill Barber
Pharmaceutical Chemistry opens with an examination of the importance of pharmaceutical chemistry. It then turns to organic structure and bonding and stereochemistry and drug action. The next chapter looks at aliphatic hydrocarbons. There follows a chapter on alcohols, phenols, ethers, organic halogen compounds, and amines. Other topics covered include the carbonyl group, aromatic chemistry, inorganic chemistry, nucleic acids, and proteins and enzymes.
Book
Humphrey A. Moynihan and Abina M. Crean
Physicochemical Basis of Pharmaceuticals explores the physical and chemical phenomena which affect the formulation and bio-availability of drug substances to give a treatment of the essential concepts affecting the absorption and distribution of drugs. The first chapter covers pharmaceuticals and medicines. The next chapter looks at pharmaceutical solutions. There follows a chapter on pharmaceutical equilibria. Then there is a chapter on the pharmaceutical solid base. The text also looks at two phase solid-liquid disperse systems and biological interfaces. The final chapter is about physiochemical aspects of pharmacokinetics and pharmacodynamics.
Book
John Saunders
Top Drugs looks at contemporary popular selling drugs. Today’s top-selling drugs have been uncovered from two major sources: natural products and laboratory synthesis. Those synthesised directly by medicinal chemists usually have been the result of a protracted discovery programme using a natural product (e.g. a hormone or an enzyme substrate) or a screening lead as a starting point. Many of the major categories of human disease-cardiovascular, gastrointestinal, central nervous system, inflammatory, and infectious diseases are included. After a short introduction to the discovery and mechanism of action of each drug, the syntheses of the best-selling drugs are reviewed. Where the information exists in the literature, the original research method to each drug is compared with more recent approaches which aim either at improving the route or at validating newer methodologies or reagents in the context of drug synthesis. Since, for many drugs, the marketed product was originally prepared as a racemic mixture, perhaps the most important comparison is between that route and alternatives which involve some element of asymmetric synthesis.
