Alicyclic Chemistry provides an overview of the study of non-aromatic organic compounds made up of one or more carbocyclic rings. Such compounds, which range from simple ring systems to complex bridged and polycyclic structures, provide a framework for the understanding of many concepts which underlie organic chemistry. The topics covered include a discussion of the stability and conformational behaviour of carbocyclic ring systems, and the factors which control the choice of synthetic methods and reactivity of such compounds. Many aspects of alicyclic chemistry provide an important framework for a proper understanding of the behaviour of organic molecules.
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Amino Acid and Peptide Synthesis introduces the study of amino acids and peptides, which is becoming increasingly important to chemists as a result of the growing overlap of mainstream organic chemistry with bioorganic chemistry and biochemistry. This introductory text begins with a brief survey of the role and diversity of amino acids, peptides, and proteins in nature, and goes on to describe and explain the principal methods of chemical synthesis.
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Malcolm Sainsbury
Aromatic Chemistry presents all the basic principles of this important topic in an account which takes as its examples many compounds of industrial and biological significance. Consideration is given to the structure, reactions, and properties of benzene and classes of aromatic compounds derived from it, and topics such as thermodynamic versus kinetic control and pericyclic reactions are introduced. The text also covers polycyclic arenes and the small and large ring systems which are embraced by the wider definition of aromaticity.
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David T. Davies
Aromatic Heterocyclic Chemistry argues that heterocyclic compounds are of prime importance to organic chemists working in the chemical industry. The emphasis of this text is on synthetic aspects rather than properties, and it covers the essential details and basic principles with reference to all the important classes of heterocyclic compounds. Instructional problems are included as an aid to comprehension, and references to more detailed texts are provided.
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Robert S. Ward
Bifunctional Compounds outlines some of the methods used to prepare bifunctional compounds and then surveys the chemistry of some of the more important classes. Most important organic molecules contain more than one functional group, and very often the interaction between these groups determines the chemical and biological behaviour of the compounds. Individual chapters look at the preparation of bifunctional compounds, reactions of dienes, of diols, of hydroxy- and aminocarbonyl compounds, of dicarbonyl compounds, and of unsaturated carbonyl compounds. The text also covers enamines, enol ethers, enolates, allyl compounds, and cyclization and polymerization.
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Benjamin G. Davis and Antony J. Fairbanks
Carbohydrate Chemistry argues that carbohydrates are a vital part not only of metabolism, but are implicated as key coding molecules in a host of subtle biological events. The exploration of the role and the manipulation of this wonderful class of molecules is an exciting and ever-changing field. This text aims to remove some of the mystery that often surrounds carbohydrate chemistry, by highlighting and summarizing some of the central principles and ideas and by illustrating them with both classical and state-of-the-art examples.
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Chemical Aspects of Biosynthesis provides a straightforward introduction to the chemistry involved in the biosynthesis of natural products. The first chapter explains the connections between primary and secondary metabolites, outlines the chemistry mediated by the major enzyme cofactors, and describes the methods for the elucidation of biosynthetic pathways. The different classes of secondary metabolites are then discussed, with emphasis placed on the pharmacological and toxicological significance of the various compounds. The final chapter offers an insight into the ecological significance of a wide variety of natural products. Suggestions for further reading are provided.
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John Jones
Core Carbonyl Chemistry starts with an introduction to the main themes in this topic. The first chapter covers nucleophilic reagents, aldehydes, and kenotes. There follows a chapter on acetals and ketals. The text also covers reactions of amino compounds with aldehydes and ketones, reactions of nucleophiles with carboxylic acid esters, and reactions of nucleophiles with other carboxylic acid derivates. There are also chapters on enols and enolates, and enolate allylations. Finally, the text looks at aldol condensations and related reactions.
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C. M. Dobson, J.A. Gerrard, and A.J. Pratt
Foundations of Chemical Biology begins by stating that chemical biology is born out of a desire to understand the molecular basis of life. It asks: what are the molecules found in cells? How do their intrinsic properties equip them to perform all the complex processes found in cells? This book introduces the fundamental chemistry of the molecules that are essential to all cells. The molecules covered include amino acids and sugar phosphate derivatives, and the macromolecules derived from them (proteins and nucleic acids respectively). This book introduces important concepts concerning their intrinsic chemistry. The aim is to provide insight into the fundamental ideas relating to the chemistry of life that can then be applied to more advanced aspects of chemical biology.
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Simon Duckett, Bruce Gilbert, and Martin Cockett
Foundations of Molecular Structure Determination begins with an overview of the topic and an examination of energy levels and the electromagnetic spectrum. The next chapter covers rotational and vibrational spectroscopy. There follows a chapter looking at electronic (ultraviolet-visible) absorption spectroscopy. The text also discusses nuclear magnetic resonance spectroscopy. The final two chapters cover mass spectrometry and X-ray diffraction and related methods.
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Michael Hornby and Josephine Peach
Foundations of Organic Chemistry offers an introduction to this subject which is at the core of chemistry. The first three chapters introduce some basic physical chemistry, and lay the groundwork for the mechanistic organic chemistry covered later in the book. The importance of bonding and mechanism are stressed throughout, and readers are encouraged to apply their chemical knowledge in new and unfamiliar situations in order to develop and sustain their interest. A wide range of examples including natural products and pharmaceuticals is included, with the final chapter exploring some new developments and providing an introduction to current research.
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Michael Hornby and Josephine Peach
Foundations of Organic Chemistry provides problems, with answers and tutorial guidance, on organic chemistry. The first three chapters cover basic physical organic chemistry, setting the scene for the mechanistic organic chemistry covered later. Chapters look at molecules, mechanisms, acids and bases, reactions with nucleophiles, reactions with electrophiles, and reactions with radical intermediates.
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Functional Groups introduces reactions of functional groups in a concise and systematic form. It covers the characteristic properties of functional groups and the methods for interconverting them, which constitute important foundations of organic chemistry. Individual chapters cover organic halides, organometallic compounds, alkanes, alkenes, alkynes, aldehydes and ketons, carboxylic acids and derivatives, ethers, and amines.
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Mark C. Elliott
How to Succeed in Organic Chemistry first lays out the foundations for the topic and looks at the basics. It talks about isomers, chemical names, how to name organic compounds, double bond equivalents, bond polarization, and electronegativity. The second section is about building on the foundations. It looks at breaking bonds, enthalpy, carbocations, carbanions, and reactivity. The third section looks at shape. The section that follows looks at types of selectivity. Section 5 is about rotating bonds and looks at cyclohexanes. The sixth section is about elimination. The seventh section is all about building skills.
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Laurence M. Harwood and Timothy D.W. Claridge
Introduction to Organic Spectroscopy aims to provide an understanding of spectroscopic techniques in the analysis of chemical structures. The book starts with an introduction to the theory. It then looks at ultra violet-visible spectroscopy. Next it considers infrared spectroscopy. Then it considers nuclear magnetic resonance spectroscopy in basic terms and then in more detail. The last chapter is about mass spectrometry.
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Howard Maskill
Mechanisms of Organic Reactions begins with the modern concepts of organic chemical reactivity, then presents an up-to-date account of the mechanisms of major reactions of simple organic compounds. Each chapter leads from the experimental evidence to the mechanistic deductions, and ends with problems and a short bibliography. Chapter 1 presents a description and investigation of organic reaction mechanisms. The next chapter looks at nucleophilic substitution at saturated carbon. There follows a chapter on the elimination reactions to give alkenes. The fourth chapter covers reactions of nucleophiles with carbonyl compounds. The final chapter examines additions to carbon-carbon multiple bonds.
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John M. Brown
Molecular Spectroscopy provides an introduction to the spectroscopy of diatomic molecules. Following a general introduction to the subject, the second chapter lays out the essential quantum mechanical tools required to understand spectroscopy. The following chapter uses this quantum mechanical framework to establish the selection rules which govern spectroscopic transitions. Chapters 4–7 describe the various branches of spectroscopy covered by the book; rotational, rotational—vibrational, Raman, and electronic spectroscopy. Quantum mechanics is used to derive formulae for the various energy levels involved and for the relative intensities of different types of transition. From these, the appearances of the different types of spectra are derived. The molecular parameters on which these spectra depend are defined and the structural information which can be derived from these is discussed.
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Workbook in Organic Chemistry begins with a look at the foundations of this subject. It then looks in more detail at isomerism, nucleophilic substitution, elimination reactions, and the reactions of unsaturated compounds. The text then moves on to focus on aromatic chemistry before examining carbonyl chemistry.
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Jonathan Clayden, Nick Greeves, and Stuart Warren
Organic Chemistry begins with the question: what is organic chemistry? Topics covered include organic structures, molecular structures, organic reactions, nucleophilic substitution, and stereochemistry. There are also chapters on conformational analysis, elimination reactions, formation and reactions of enols and enolates, and chemoselectivity. The text moves on to consider regioselectivity, alkylation and reaction of enolates, retrosynthetic analysis, and aromatic horocycles. There is also coverage of stereoselectivity, diastereoselectivity, pericyclic reactions, and radical reactions. Finally, towards the end, the text looks at synthesis and reactions of carbenes, how to determine reaction mechanisms, organometallic chemistry, asymmetric synthesis, and organic chemistry today.
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Tadashi Okuyama and Howard Maskill
Organic Chemistry
begins by looking at chemical bonding and molecules. The text moves on to molecular structure and the shape of organic molecules. Other topics covered include organic compounds, conjugation, pi-electron delocalization, aromaticity, acids and bases. Chapters also examine organic reactions, nucleophilic addition, stereochemistry, reactions of alcohols and addition reactions of alkenes and alkynes. There are also chapters on enolate anions, enolate ions, and reactions of nucleophiles with alkenes and aromatic compounds. The text next turns to polycyclic and heterocyclic aromatic compounds, rearrangement reactions, pericyclic reactions, and rearrangement reactions involving polar molecules and ions. Finally, the text discusses biomolecules, chemistry of biomolecules, and the structural determination of organic compounds.
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