Biology of Disease provides an integrated introduction to the basic cell biology that underlies disease processes and the diagnosis and management of those diseases. By telling the whole story of how a disease develops, how it is diagnosed, and how it is treated, the text provides an understanding of both the molecular and clinical aspects of diseases. Featuring a wide range of diseases, the text places particular emphasis on diseases that biomedical scientists and other health care professionals are most likely to encounter in a clinical setting and that have the greatest impact on people's lives. This is reflected in the book's detailed coverage of cancer and cardiovascular disease, which have long been causing many deaths each year, and its discussion of the COVID-19 pandemic. The inclusion of clinical case studies throughout shows how the theory of disease processes informs the diagnosis and treatment of different diseases in practice.
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Nessar Ahmed
Clinical Biochemistry
covers the core topics in the field of biochemistry, placing it in the context of human disease. Throughout the text, the theory is continually related to laboratory practice through the use of examples and case studies. Topics covered include biochemical investigations and quality control, automation, kidney disease, hyperuricaemia, gout, and fluid and electrolyte disorders. The text also looks at acid-based disorders, liver function, lipid metabolism, and other disorders such as disorders of calcium, phosphate, and magnesium homeostasis. Thyroid disease is covered. Cancer biochemistry is an important topic here and the text also examines tumour markers. There is a chapter on newborn screening and inherited metabolic disorders. Finally, the text considers chemical toxicology.
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Angela Hall, Chris Scott, and Matthew Buckland
Clinical Immunology introduces the topic with an assessment of the clinical immunology laboratory. It then looks at immunoglobulins. The subject of allergies is examined next. The text contains a chapter that tackles autoimmune rheumatological disease and another chapter looks at autoimmune kidney disease. The text moves on to examine organ-specific autoimmunity. Other autoimmune diseases considered include autoimmune skin disease and autoimmune liver disease. The book also discusses neuroimmunology, flow cytometry, and primary immunodeficiency. Finally, the human immunodeficiency virus (HIV) is discussed. The book ends with a look at histocompatibility and immunogenetics.
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Edited by Behdad Shambayati
Cytopathology begins with an introduction to the topic. It then discusses preparation techniques, the cervical screening process, normal cervical cytology and abnormal cervical cytology, and quality issues in cervical screening. There are also chapters that cover diagnostic cytopathology, cytology of urine, serious effusions and peritoneal washings, lower respiratory tract cytology, and fine needle aspiration cytology. The text then goes on to examine basic semen analysis, cytopathology of the biliary tract and pancreas, advances in cytopathology, data analysis, and expertise in cytopathology.
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Edited by Guy Orchard and Brian Nation
Histopathology first asks: what is histopathology? It then looks at fixation and specimen handling. Topics covered include data recording and histopathology dissection, routine staining, special stains, artefacts, and Mohs procedures. The text moves on to examine immunocytochemical techniques and analytical immunocytochemistry. Next, there is a chapter on
in situ
hybridization. This is followed by a couple of chapters on molecular diagnostics. Histopathology reporting is dealt with after that. Finally, the text discusses microscopy and digital pathology, electron microscopy in diagnosis, mortuary practice, and the essentials of laboratory management.
Book
Stephen J. Juris
Immunology introduces this discipline, which is a subject containing vast amounts of detail. The immune system is vastly complex. This text tries to unravel the mysteries of immunology through accounts of classical discoveries and recent, cutting-edge research. The text starts with an introduction to the subject. There follows chapters on innate immunity, the complement system, and adaptive immunity. Chapters then cover T Lymphocytes, the development of B Lymphocytes, and B-cell diversity. The text also looks into immunological memory and vaccination, mucosal immunity, and pathogen evasion of the immune system. Immunodeficiencies are covered. As are allergies and hypersensitivity. Autoimmune diseases are the subject of another chapter. The text ends with two chapters looking at transplantation, immune responses to transplantation, and cancer of the immune system.
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John H.L. Playfair and Gregory J. Bancroft
Infection & Immunity
gives an overview looking at immunity with respect to infection. It describes the key infectious agents our bodies encounter and how our immune system responds to them. It also explains how diseases are spread and what measures we can take to control this spread, from vaccination to increasing public awareness. Chapters cover topics such as HIV, TB, and malaria. The text then goes on to look at infantile diarrhoea and respiratory disease. Chapters also considers innate recognition, cell signalling, cancer, and pregnancy.
Book
Michael Ford
Medical Microbiology covers a range of key laboratory techniques used in the diagnosis of human diseases caused by microorganisms, with case studies throughout to highlight the clinical relevance of the techniques being described. The text is written from the point of view of a laboratory biomedical scientist. Topics include whole genome sequencing; MALDI-TOF, air sampling, and food microbiology; congenital infections, syphilis, human papillomavirus infection, and sample processing; the detection of antimicrobial resistance by molecular methods; and progressive cognitive disease, high-level resistance, and faecal transplantation.
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Edited by Anthony Warford and Nadège Presneau
Molecular Diagnostics provides an introduction to molecular techniques and their applications to diagnostic pathology to illustrate the scope of molecular analysis in biomedical science, the principles of the technology used, and thematic diagnostic application. The first chapter looks at sample preparation and is followed by chapters covering the molecular laboratory, intact sample analysis, and homogenate sample analysis. Other topics covered include sequence technologies, molecular analysis and the interpretation of molecular data, technical advances in molecular analysis, and haemopoietic diseases. Finally, the text considers different types of tumours and pre-natal and neo-natal testing.
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Anne C. Cunningham
Thrive in Immunology first provides a detailed introduction to immune responses and looks specifically at cells, mediators, and structures and it asks: how is the immune system activated? It then considers what the immune system destroys. Finally, at the end of the text, the last section consider the role of the immune system in health and disease.
